Clinical Trials

Our participation in clinical trials

At NJ Retina, our physicians are actively involved in research as part of a host of multicentered clinical trials on new therapeutic approaches to retinal diseases. We have participated in a numerous national eye research studies, including:

Non-exudative “Dry” Age-Related Macular Degeneration (AMD) Studies

Currently Enrolling

  • Pfizer B1181003  Multiple doses of RN6G by infusion in patients with Geographic Atrophy secondary to Age-Related Macular Degeneration.

Completed Study

Neovascular “Wet” Age-Related Macular Degeneration (AMD) Studies

Currently Enrolling

  • Lpath Nexus LT1009-Oph-003 4 monthly injections of iSonep given alone or in combination with Lucentis or Avastin in patients with wet AMD.
  • OHR-002  Ophthalmic drops (Squalamine Lactate) in patients with wet AMD
  • Alcon C-12-006  Injections of ESBA 1008 versus Eylea in subjects with wet AMD.

Completed Studies 

  • VGFT-OD-0508  Intravitreal Injection of VEGF Trap in patients with wet AMD.
  • VGFT-OD-0702  Phase 2 study of VEGF Trap injections in patients with wet AMD.
  • VGFT-OD-0605  Phase 3 study of VEGF Trap injections in patients with wet AMD.
  • Harbor  Ranibizumab injections administered on monthly or as needed basis in patients with wet AMD.
  • CATT  Comparison Study of Lucentis versus Avastin in patients with wet AMD.
  • Denali  Comparison Study of Lucentis alone versus Lucentis plus photodynamic therapy in patients with wet AMD.

Diabetic Retinopathy Studies 

Ongoing but not enrolling

  • Rise  Ranibizumab Injection in patients with clinically significant macular edema with center involvement secondary to Diabetes.
  • VGFT-OD-1009  Intravitreal Injections of VEGF Trap-Eye in patients with Diabetic Macular Edema.
  • Quark QRK202  2 part study.  Part 1 – determines maximum tolerated dose of PF-04523655.  Part 2 – Study of PF-04523655 used alone and in combination with ranibizumab versus ranibizumab alone in patients with Diabetic Macular Edema.

Completed Studies

  • VGFT-OD-0706  Phase 2 study of intravitreal injections of VEGF Trap-Eye in patients with Diabetic Macular Edema.

Retinal Vein Occlusion

Currently enrolling

  • Allergan  Comparing visual improvement and total number of intraocular injections in patients with macular edema following central retinal vein occlusion (CRVO) after initial treatment with Ozurdex or Avastin.

Completed Studies

  • CRUISE  Study of Lucentis injections in patients with macular edema secondary to central retinal vein occlusion (CRVO).
  • BRAVO  Study of Lucentis injections in patients with macular edema secondary to branch retinal vein occlusion (BRVO).
  • SCORE  Study of Triamcinolone injections in patients with macular edema associated with central retinal vein occlusion (CRVO) and branch retinal vein occlusion (BRVO).

Uveitis Studies

Currently Enrolling

  • 32-007  Phase 3 study of Intravitreal injections of DE-109 in patients with active, non-infectious uveitis of the posterior segment of the eye.

Vitreomacular Adhesion Studies

Ongoing but not enrolling

  • TG-MV-014  Study of Ocriplasmin in patients with symptomatic vitreomacular adhesion/(VMT) including macular hole.

Completed Studies

  • TG-MV-005  Ocriplasmin injection in patients with wet AMD/focal vitreomacular adhesion.

To learn more about these clinical trials, visit www.clinicaltrials.gov

For patients interested in enrolling in a clinical trial

Numerous clinical trials are available to appropriate NJ Retina patients for a variety of retinal conditions. If you are interested in determining if you might be eligible for a clinical trial, request an appointment at our office.